Authors and Affiliations
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London Tubular Centre, Department of Renal Medicine, University College London, London, UK
Keith Siew, Viola D’Ambrosio, Chutong Zhong, Zhongwang Li, Alessandra Grillo, Elizabeth R. Wan & Stephen B. Walsh
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The Institute for Biomedical Sciences (IBS), The George Washington University, Washington, DC, USA
Kevin A. Nestler
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Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA
Charlotte Nelson & Sergio Baranzini
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Department of Experimental and Translational Medicine, Università Cattolica del Sacro Cuore di Roma, Rome, Italy
Viola D’Ambrosio
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Centre for Advanced Biomedical Imaging, University College London, London, UK
Zhongwang Li & Simon Walker-Samuel
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Centre for Computational Medicine, University College London, London, UK
Zhongwang Li & Simon Walker-Samuel
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Department of Renal Medicine, University College London, London, UK
Vaksha Patel, Omid Sadeghi-Alavijeh & Jasminka Godovac-Zimmermann
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Institute for Computational Biomedicine, Weill Cornell Medical College, New York, NY, USA
Eliah Overbey, JangKeun Kim, Cem Meydan & Annalise Schweickart
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University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
Sanghee Yun
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Department of Anesthesiology and Critical Care Medicine, Children’s Hospital of Philadelphia, Philadelphia, PA, USA
Sanghee Yun, Frederico C. Kiffer & Amelia J. Eisch
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School of Medicine, College of Medicine and Health, University College Cork, Cork, Ireland
Michael B. Vaughan & Anthony L. Marullo
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Tissue Engineering and Biomaterials Group, Ghent University, Ghent, Belgium
Michael B. Vaughan
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Center for Medical Genetics, Department of Biomolecular Medicine, Ghent University, Ghent, Belgium
Michael B. Vaughan
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Bioinformatics and Computational Biology Laboratory, The Francis Crick Institute, London, UK
Chris Cheshire
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Applied Biotechnology Laboratory, The Francis Crick Institute, London, UK
Laura Cubitt, Nourdine Bah & Samuel Rodriques
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Sainsbury Wellcome Centre for Neural Circuits and Behaviour, University College London, London, UK
Jessica Broni-Tabi, Peter Gordon & Robert A. A. Campbell
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Anti-Doping Laboratory Qatar, Doha, Qatar
Maneera Yousef Al-Jaber, Mohammed Al-Maadheed & Vidya Mohamed-Alis
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Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA, USA
Valery Boyko, Alison French, Samrawit Gebre, Lauren M. Sanders, Sylvain V. Costes, Eduardo A.C.Almeida & Jonathan M. Galazka
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MRC MDU Mouse Biochemistry Laboratory, University of Cambridge, Cambridge, UK
Peter Barker & Keith Burling
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Center for Data Driven Discovery in Biomedicine, Children’s Hospital of Philadelphia, Philadelphia, PA, USA
Shehbeel Arif
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Division of Neurosurgery, Children’s Hospital of Philadelphia, Philadelphia, PA, USA
Shehbeel Arif
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Department of Medicine—Nephrology & Intelligent Critical Care Center, University of Florida, Gainesville, FL, USA
Fatemeh Afsari, Samuel Border, Nicholas Lucarelli, Sayat Mimar, Ahmed Naglah & Anindya S. Paul
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Department of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, NY, USA
Noah Allen, Margareth Cheng-Campbell, Angela Kubik & Elizabeth Blaber
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Centre of Metabolism and Inflammation, University College London, London, UK
Mohammed Al-Maadheed & Vidya Mohamed-Alis
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School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
Selin Altinok
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Pharmacology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
Amanda L. Brown, Colleen M. McCann, Leah Oswalt, Rebekah Sanchez-Hodge & Jonathan C. Schisler
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Blue Marble Space Institute of Science, Seattle, WA, USA
Margareth Cheng-Campbell, Lorraine Christine De Oliveira, Lauren M. Sanders & Fathi Karouia
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Department of Anesthesiology and Critical Care Medicine, Children’s Hospital of Philadelphia Research Institute, Philadelphia, PA, USA
Lorianna M. Colón
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KBR, Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA, USA
Lovorka Degoricija, San-huei Lai Polo, Ryan T. Scott, Amanda M. Saravia-Butler & Afshin Beheshti
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Department of Medicine, University of Cambridge, Cambridge, UK
Nichola Figg
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School of Health, Science and Wellbeing, Staffordshire University, Stoke-on-Trent, UK
Rebecca Finch & Willian A. da Silveira
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Department of Physiology and Biophysics, Weill Cornell Medical College, New York, NY, USA
Jonathan Foox & Christopher E. Mason
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The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medical College, New York, NY, USA
Jonathan Foox & Christopher E. Mason
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Monash Proteomics and Metabolomics Platform, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia
Pouya Faridi, Hossein Valipour Kahrood, Han-Chung Lee, Ralf Bernd Schittenhelm, Terry Chin Choy Lim Kam Sian, Erwin Tanuwidjaya, Haijian Zhang & Joel Ricky Steele
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Physiology, Biophysics & Systems Biology, Weill Cornell Medical College, New York, NY, USA
Nadia Houerbi
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Monash Bioinformatics Platform, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia
Hossein Valipour Kahrood
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Division of Experimental Medicine & Immunotherapeutics (EMIT), Department of Medicine, University of Cambridge, Cambridge, UK
Aleksandra S. Klosinska, Kevin M. O’Shaughnessy & Yasmin
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State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center, Beijing, China
Yinghui Li & Zhongquan Dai
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Cornell Center for Immunology, Cornell University, Ithaca, NY, USA
Irina Matei
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Children’s Cancer and Blood Foundation Laboratories, Departments of Pediatrics and Cell and Developmental Biology, Drukier Institute for Children’s Health, Meyer Cancer Center, Weill Cornell Medical College, New York, NY, USA
Irina Matei
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Advanced Sequencing Facility, The Francis Crick Institute, London, UK
Jérôme Nicod, María Rodríguez-Lopez, Hubert Slawinski & Daniel Snell
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Federal University of São Paulo (UNIFESP), São Paulo, Brazil
Lorraine Christine De Oliveira
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Pediatrics, Weill Cornell Medical College, New York, NY, USA
Laura Ioana Patras
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Department of Immunology and Inflammation, Imperial College London, London, UK
Candice Roufosse
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Englander Institute for Precision Medicine, Weill Cornell Medical College, New York, NY, USA
Annalise Schweickart
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International Space University, 67400, Illkirch-Graffenstaden, France
Willian A. da Silveira
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University Health Network, Toronto, ON, Canada
Julio Sosa
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Department of Agricultural and Biological Engineering, Purdue University, West Lafayette, IN, USA
Marshall Tabetah
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Proteomics, King’s College London, London, UK
Xiaoping Yang & Steven Lynham
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Department of Medicine-Quantitative Health Section, University of Florida, Gainesville, FL, USA
Pinaki Sarder
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Departments of Biomedical Engineering and Electrical and Computer Engineering, University of Florida, Gainesville, FL, USA
Pinaki Sarder
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Space Research Within Reach, San Francisco, CA, USA
Fathi Karouia
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Center for Space Medicine, Baylor College of Medicine, Houston, TX, USA
Fathi Karouia
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Department of Biomedical and Health Informatics, Children’s Hospital of Philadelphia Research Institute, Philadelphia, PA, USA
Hossein Fazelinia
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Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan
Akira Uruno & Masayuki Yamamoto
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Mouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Tsukuba, Ibaraki, Japan
Dai Shiba
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JEM Utilization Center, Human Spaceflight Technology Directorate, Japan Aerospace Exploration Agency (JAXA), Tsukuba, Ibaraki, Japan
Dai Shiba
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Department of Medical Biochemistry, Graduate School of Medicine, Tohoku University, Sendai, Miyagi, Japan
Masayuki Yamamoto
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Center for Biotechnology & Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY, USA
Elizabeth Blaber
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Stanley Center for Psychiatric Research, Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA
Elizabeth Blaber
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Department of Neuroscience, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
Amelia J. Eisch
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Institute of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan
Masafumi Muratani
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Department of Preventative Medicine and Community Health, University of Texas Medical Branch, Galveston, TX, USA
Sara R. Zwart
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NASA Johnson Space Center, Houston, TX, USA
Scott M. Smith
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The WorldQuant Initiative for Quantitative Prediction, Weill Cornell Medical College, New York, NY, USA
Christopher E. Mason
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The Feil Family Brain and Mind Research Institute, Weill Cornell Medical College, New York, NY, USA
Christopher E. Mason
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Broad Institute, Cambridge, MA, USA
Afshin Beheshti
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Space Biosciences Division, Universities Space Research Association (USRA), Washington, DC, USA
Afshin Beheshti
Contributions
K.S., S.B.W. conceived the study and were responsible for project management. A.J.E., A.B., J.M.G., R.T.S., K.S., S.B.W., V.P., M.M., C.E.M. were involved in conceptualisation of the study. M.Y.A.J., V.M.A., F.K., L.C.D.O., L.M.S., H.F., I.M., S.M.S., C.R., S.L., X.Y., E.T., H.C.L., H.V.K., H.Z., J.R.S., P.F., R.B.S., T.C.C.L.K.S., A.B., A.F., J.M.G., L.D., R.T.S., S.G., S.L.P., S.V.C., V.B., A.S.B., R.F., W.A.D.S., C.C., D.S., H.S., J.N., L.C., M.R.L., N.B., S.R., K.A.N., J.C.S., V.D.A., M.B.V., A.G., C.Z., E.R.W., J.B.T., J.G.Z., K.S., M.A.M., P.G., R.A.A.C., S.B.W., S.W.S., V.P., J.S., C.N., S.B., K.B., K.M.O., N.F., P.B., Y., A.N., F.A., N.L., P.S., S.B.2., S.M., A.S., S.R.Z., M.M., A.S.2, C.E.M., C.M., E.O., J.F., J.K., L.I.P., N.H. developed the methodology. L.M.S., A.J.E., F.C.K., L.M.C., D.Z., Y.L., I.M., S.M.S., D.S.2., S.L., X.Y., A.B., A.F., J.M.G., L.D., R.T.S., S.G., S.L.P., S.V.C., V.B., A.S.B., E.A.C.A., A.K., M.C.C., D.S., H.S., J.N., L.C., M.R.L., S.R., J.C.S., A.L.B., C.M.M., L.O., R.S.H., S.A., A.U., M.Y., V.D.A., E.B., A.G., C.Z., E.R.W., J.B.T., K.S., .P.G., R.A.A.C., V.P., Z.L., A.S.K., K.B., N.F., P.B., Y., S.Y., S.R.Z., M.M., A.S.2., C.E.M., C.M., E.O., J.F., J.K., L.I.P., N.H. carried out the experiments and investigation of the samples. M.Y.A.J., V.M.A., F.K., L.C.D.O., L.M.S., S.A.2, H.F., I.M., S.M.S., C.R., D.S.2, S.L., X.Y., E.T., H.C.L., H.V.K., H.Z., J.R.S., P.F., R.B.S., T.C.C.L.K.S., A.B., A.F., J.M.G, L.D., R.T.S., S.G., S.L.P., S.V.C., V.B., A.S.B., M.T., R.F., W.A.D.S., C.C., L.C., N.B., S.R., K.A.N., J.C.S., A.L.B., C.M.M., R.S.H., A.U., M.Y., V.D.A., A.L.M., M.B.V., A.G., C.Z., E.R.W., M.A.M., O.S.A., S.W.S., V.P., C.N., S.B., K.M.O., Y., S.R.Z., M.M., A.S.2., C.E.M., C.M., E.O., J.F., J.K., L.I.P, N.H. contributed to the analysis and interpretation of the results. L.M.S., A.E., F.C.K., L.M.C., D.Z., Y.L., IM, SMS, DS2, A.B., A.F., J.M.G., L.D., R.T.S., S.G., S.L.P., S.V.C., V.B., A.S.B., E.A.C.A., A.K,. M.C.C., J.C.S., L.O., R.S.H., S.A., A.U., M.Y., E.B., S.Y., S.R.Z., M.M., A.S.2., C.E.M., C.M., E.O., J.F., J.K., L.I.P., N.H. provided the study resources. V.D.A., A.G., C.Z., E.R.W., K.S., S.B.W., V.P., Z.L. contributed to the original drafting of the manuscript. M.Y.A.J., V.M.A., F.K., L.C.D.O., L.M.S., A.J.E, F.C.K., S.A.2, H.F., L.M.C., D.Z., Y.L., I.M., S.M.S., C.R., D.S.2., S.L., X.Y., E.T., H.C.L., H.V.K., H.Z., J.R.S., P.F., R.B.S., T.C.C.L.K.S., A.B., A.F., J.M.G., L.D., R.T.S., S.G., S.L.P., S.V.C., V.B., A.S.B., E.A.C.A., M.T., A.K., M.C.C., R.F., W.A.D.S., C.C., D.S., H.S., J.N., L.C., M.R.L., N.B., S.R., K.A.N., J.C.S., L.O., R.S.H., S.A., A.U., M.Y., V.D.A., E.B., A.L.M., M.B.V., A.G., C.Z., E.R.W., J.B.T., J.G.Z., K.S., M.A.M., O.S.A., P.G., R.A.A.C., S.B.W., S.W.S., V.P., Z.L., J.S., C.N., S.B., A.S.K., K.B., K.M.O., N.F., P.B., Y., A.N., F.A., N.L., P.S., S.B.2, S.M., A.S., S.Y., S.R.Z., M.M., A.S.2, C.E.M., C.M., E.O., J.F., J.K., L.I.P., NH provided critical feedback and helped shape the study and edit the manuscript. M.Y.A.J., S.A.2, C.C., K.A.N., J.C.S., V.D.A., M.B.V., A.G., C.Z., E.R.W., K.S., S.B.W., Z.L., C.N., S.B. planned and designed the figures and visualisation of results. V.M.A., F.K., L.M.S., A.J.E., D.Z., S.M.S., D.S.2, S.L., J.R.S., A.B., J.M.G., R.T.S., S.G., S.V.C., A.S.B., W.A.D.S., C.C., J.N., L.C., S.R., J.C.S., M.Y., E.B., M.B.V., K.S., M.A.M., R.A.A.C., S.B.W., S.W.S., V.P., S.B., K.B., P.B., Y., P.S., S.Y., S.R.Z., M.M., C.E.M., E.O., J.K. supervised this project.
Corresponding authors
Correspondence to
Keith Siew or Stephen B. Walsh.
