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Role of OPG/RANKL/RANK/TLR4 signaling pathway in sepsis-associated acute kidney injury – BMC Nephrology

  • Wang X, Wang Y, Kong M, Yang J. MiR-22-3p suppresses sepsis-induced acute kidney injury by targeting PTEN. Biosci Rep 2020, 40(6).

  • Perner A, Cecconi M, Cronhjort M, Darmon M, Jakob SM, Pettila V, van der Horst ICC. Expert statement for the management of hypovolemia in sepsis. Intensive Care Med. 2018;44(6):791–8.

    Article 
    PubMed 

    Google Scholar
     

  • May CN, Bellomo R, Lankadeva YR. Therapeutic potential of megadose vitamin C to reverse organ dysfunction in sepsis and COVID-19. Br J Pharmacol. 2021;178(19):3864–8.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Zarbock A, Nadim MK, Pickkers P, Gomez H, Bell S, Joannidis M, Kashani K, Koyner JL, Pannu N, Meersch M, et al. Sepsis-associated acute kidney injury: consensus report of the 28th Acute Disease Quality Initiative workgroup. Nat Rev Nephrol. 2023;19(6):401–17.

    Article 
    PubMed 

    Google Scholar
     

  • Poston JT, Koyner JL. Sepsis associated acute kidney injury. BMJ. 2019;364:k4891.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Petejova N, Martinek A, Zadrazil J, Kanova M, Klementa V, Sigutova R, Kacirova I, Hrabovsky V, Svagera Z, Stejskal D. Acute Kidney Injury in Septic Patients Treated by Selected Nephrotoxic Antibiotic Agents-Pathophysiology and Biomarkers-A Review. International journal of molecular sciences 2020, 21(19).

  • Xiao J, Yang Q, Zhang Y, Xu H, Ye Y, Li L, Yang Y, Jin S. Maresin conjugates in tissue regeneration-1 suppresses ferroptosis in septic acute kidney injury. Cell Bioscience. 2021;11(1):221.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • van Dam PA, Verhoeven Y, Trinh XB, Wouters A, Lardon F, Prenen H, Smits E, Baldewijns M, Lammens M. RANK/RANKL signaling inhibition may improve the effectiveness of checkpoint blockade in cancer treatment. Crit Rev Oncol Hematol. 2019;133:85–91.

    Article 
    PubMed 

    Google Scholar
     

  • Dufresne SS, Dumont NA, Boulanger-Piette A, Fajardo VA, Gamu D, Kake-Guena SA, David RO, Bouchard P, Lavergne É, Penninger JM, et al. Muscle RANK is a key regulator of Ca2 + storage, SERCA activity, and function of fast-twitch skeletal muscles. Am J Physiol Cell Physiol. 2016;310(8):C663–672.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Mota RF, Cavalcanti de Araujo PH, Cezine MER, Matsuo FS, Metzner RJM, Oliveira de Biagi Junior CA, Peronni KC, Hayashi H, Shimamura M, Nakagami H et al. RANKL Impairs the TLR4 Pathway by Increasing TRAF6 and RANK Interaction in Macrophages. BioMed research international 2022, 2022:7740079.

  • Tsukamoto H, Takeuchi S, Kubota K, Kobayashi Y, Kozakai S, Ukai I, Shichiku A, Okubo M, Numasaki M, Kanemitsu Y, et al. Lipopolysaccharide (LPS)-binding protein stimulates CD14-dependent toll-like receptor 4 internalization and LPS-induced TBK1-IKKϵ-IRF3 axis activation. J Biol Chem. 2018;293(26):10186–201.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Xu W, Xie J, Chen X. H2S alleviates urinary Sepsis-Induced Acute kidney Injury by inhibiting the TLR4/MyD88/PI3K signaling pathway. Chin J Pathophysiology. 2019;35(2):243–7.


    Google Scholar
     

  • Yang J, Xu H, Wang B, Wang Y, Cao S. Study on platelet activation status and IL-18 expression in septic rats. Practical J Shock. 2018;2(2):83–6.


    Google Scholar
     

  • Ying J, Wu J, Yao L. Protective effect of Ligustrazine on endothelial cells in mice with acute kidney Injury Induced by Sepsis. Zhejiang Med. 2021;43(2):138–42.


    Google Scholar
     

  • Markwart R, Saito H, Harder T, Tomczyk S, Cassini A, Fleischmann-Struzek C, Reichert F, Eckmanns T, Allegranzi B. Epidemiology and burden of sepsis acquired in hospitals and intensive care units: a systematic review and meta-analysis. Intensive Care Med. 2020;46(8):1536–51.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Weng L, Zeng XY, Yin P, Wang LJ, Wang CY, Jiang W, Zhou MG, Du B, China Critical Care Clinical Trials G. Sepsis-related mortality in China: a descriptive analysis. Intensive Care Med. 2018;44(7):1071–80.

    Article 
    PubMed 

    Google Scholar
     

  • Wijayaratne D, Wijewickrama E. Acute kidney injury in sepsis. Sri Lanka J Surg. 2017;35(6):15–25.

    Article 

    Google Scholar
     

  • Fan H, Zhao Y, Chen GD, Sun M, Zhu JH. Health insurance status and risk factors of mortality in patients with septic acute kidney injury in Ningbo, China. J Int Med Res. 2019;47(1):370–6.

    Article 
    PubMed 

    Google Scholar
     

  • De Voogd FA, Gearry RB, Mulder CJ, Day AS. Osteoprotegerin: a novel biomarker for inflammatory bowel disease and gastrointestinal carcinoma. J Gastroenterol Hepatol. 2016;31(8):1386–92.

    Article 
    PubMed 

    Google Scholar
     

  • Xue W. Serum OPG levels and their clinical significance in patients with cirrhosis complicated by Acute kidney Injury. Lab Med Clin. 2020;17(14):2080–1.

    CAS 

    Google Scholar
     

  • Kemperman H, Schrijver IT, Roest M, Kesecioglu J, van Solinge WW, de Lange DW. Osteoprotegerin is higher in Sepsis Than in Noninfectious SIRS and predicts 30-Day mortality of SIRS patients in the Intensive Care. J Appl Lab Med. 2019;3(4):559–68.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Schaalan M, Mohamed W. Predictive ability of circulating osteoprotegerin as a novel biomarker for early detection of acute kidney injury induced by sepsis. Eur Cytokine Netw. 2017;28(2):52–62.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Melagraki G, Leonis G, Ntougkos E, Rinotas V, Papaneophytou C, Mavromoustakos T, Kontopidis G, Douni E, Kollias G, Afantitis A. Current status and future prospects of small-molecule protein-protein Interaction (PPI) inhibitors of Tumor Necrosis factor (TNF) and receptor activator of NF-kappaB ligand (RANKL). Curr Top Med Chem. 2018;18(8):661–73.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Francisconi CF, Vieira AE, Azevedo MCS, Tabanez AP, Fonseca AC, Trombone APF, Letra A, Silva RM, Sfeir CS, Little SR, et al. RANKL triggers treg-mediated Immunoregulation in Inflammatory Osteolysis. J Dent Res. 2018;97(8):917–27.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Kobayashi-Sakamoto M, Maeda T, Yusa J, Kato Y, Kiyoura Y. RANK-RANKL signaling upregulates Il-10 mRNA expression in mucosal Candida infection in vivo. Microb Pathog. 2020;149:104285.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Rochette L, Meloux A, Rigal E, Zeller M, Malka G, Cottin Y, Vergely C. The role of Osteoprotegerin in vascular calcification and bone metabolism: the basis for developing new therapeutics. Calcif Tissue Int. 2019;105(3):239–51.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Maruyama K, Takada Y, Ray N, Kishimoto Y, Penninger JM, Yasuda H, Matsuo K. Receptor activator of NF-kappa B ligand and osteoprotegerin regulate proinflammatory cytokine production in mice. J Immunol. 2006;177(6):3799–805.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Wang Y, Zhang S, Li H, Wang H, Zhang T, Hutchinson MR, Yin H, Wang X. Small-molecule modulators of toll-like receptors. Acc Chem Res. 2020;53(5):1046–55.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Kuzmich NN, Sivak KV, Chubarev VN, Porozov YB, Savateeva-Lyubimova TN, Peri F. TLR4 signaling pathway modulators as potential therapeutics in inflammation and Sepsis. Vaccines. 2017;5(4):34.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Swanson L, Katkar GD, Tam J, Pranadinata RF, Chareddy Y, Coates J, Anandachar MS, Castillo V, Olson J, Nizet V, et al. TLR4 signaling and macrophage inflammatory responses are dampened by GIV/Girdin. Proc Natl Acad Sci U S A. 2020;117(43):26895–906.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Peerapornratana S, Manrique-Caballero CL, Gomez H, Kellum JA. Acute kidney injury from sepsis: current concepts, epidemiology, pathophysiology, prevention and treatment. Kidney Int. 2019;96(5):1083–99.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Valles PG, Gil Lorenzo AF, Garcia RD, Cacciamani V, Benardon ME, Costantino VV. Toll-like receptor 4 in Acute kidney Injury. Int J Mol Sci 2023, 24(2).