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CUX1 attenuates the apoptosis of renal tubular epithelial cells induced by contrast media through activating the PI3K/AKT signaling pathway – BMC Nephrology

  • Yoon SY, Kim JS, Jeong KH, Kim SK. Acute Kidney Injury: Biomarker-Guided Diagnosis and Management. Medicina (Kaunas, Lithuania). 2022;58(3).

  • Fähling M, Seeliger E, Patzak A, Persson PB. Understanding and preventing contrast-induced acute kidney injury. Nat Rev Nephrol. 2017;13(3):169–80.

    Article 
    PubMed 

    Google Scholar
     

  • Ramachandran P, Jayakumar D. Contrast-induced acute kidney Injury. Indian journal of critical care medicine: peer-reviewed. Official Publication Indian Soc Crit Care Med. 2020;24(Suppl 3):S122–5.

    CAS 

    Google Scholar
     

  • Chandiramani R, Cao D, Nicolas J, Mehran R. Contrast-induced acute kidney injury. Cardiovasc Intervention Ther. 2020;35(3):209–17.

    Article 

    Google Scholar
     

  • Patidar KR, Shamseddeen H, Xu C, Ghabril MS, Nephew LD, Desai AP, et al. Hospital-Acquired Versus Community-Acquired Acute kidney Injury in patients with cirrhosis: a prospective study. Am J Gastroenterol. 2020;115(9):1505–12.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Azzalini L, Kalra S. Contrast-Induced Acute kidney Injury-Definitions, Epidemiology, and implications. Interventional Cardiol Clin. 2020;9(3):299–309.

    Article 

    Google Scholar
     

  • Vlachopanos G, Schizas D, Hasemaki N, Georgalis A. Pathophysiology of contrast-Induced Acute kidney Injury (CIAKI). Curr Pharm Design. 2019;25(44):4642–7.

    Article 
    CAS 

    Google Scholar
     

  • Sůva M, Kala P, Poloczek M, Kaňovský J, Štípal R, Radvan M, et al. Contrast-induced acute kidney injury and its contemporary prevention. Front Cardiovasc Med. 2022;9:1073072.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Yun D, Kim DK, Lee JP, Kim YS, Oh S, Lim CS. Can sodium fluorescein cause contrast-induced nephropathy? Nephrology, dialysis, transplantation: official publication of the European Dialysis and Transplant Association -. Eur Ren Association. 2021;36(5):819–25.

  • Liu N, Sun Q, Wan L, Wang X, Feng Y, Luo J, et al. CUX1, a controversial player in Tumor Development. Front Oncol. 2020;10:738.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Supper E, Rudat S, Iyer V, Droop A, Wong K, Spinella JF, et al. Cut-like homeobox 1 (CUX1) tumor suppressor gene haploinsufficiency induces apoptosis evasion to sustain myeloid leukemia. Nat Commun. 2021;12(1):2482.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Burton LJ, Hawsawi O, Sweeney J, Bowen N, Hudson T, Odero-Marah V. CCAAT-displacement protein/cut homeobox transcription factor (CUX1) represses estrogen receptor-alpha (ER-α) in triple-negative breast cancer cells and can be antagonized by muscadine grape skin extract (MSKE). PLoS ONE. 2019;14(4):e0214844.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Imgruet MK, Lutze J, An N, Hu B, Khan S, Kurkewich J, et al. Loss of a 7q gene, CUX1, disrupts epigenetically driven DNA repair and drives therapy-related myeloid neoplasms. Blood. 2021;138(9):790–805.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Sharma M, Fopma A, Brantley JG, Vanden Heuvel GB. Coexpression of Cux-1 and notch signaling pathway components during kidney development. Dev Dyn. 2004;231(4):828–38.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Livingston S, Carlton C, Sharma M, Kearns D, Baybutt R, Vanden Heuvel GB. Cux1 regulation of the cyclin kinase inhibitor p27(kip1) in polycystic kidney disease is attenuated by HDAC inhibitors. Gene. 2019;721s:100007.

    Article 
    PubMed 

    Google Scholar
     

  • Wang Z, Shang J, Li Z, Li H, Zhang C, He K, et al. PIK3CA is regulated by CUX1, promotes cell growth and metastasis in bladder Cancer via activating epithelial-mesenchymal transition. Front Oncol. 2020;10:536072.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Chen C, Sun L, Zhang W, Tang Y, Li X, Jing R, et al. Limb ischemic preconditioning ameliorates renal microcirculation through activation of PI3K/Akt/eNOS signaling pathway after acute kidney injury. Eur J Med Res. 2020;25(1):10.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Zhang L, Li P, Zhang BL, Yu ML, Xu RL, Wu H, et al. Dysregulation of HULC promotes contrast-induced nephropathy (CIN) via regulating signaling pathway of miRNA-512 and prostaglandin E1 (PGE(1)). Sci Rep. 2020;10(1):11691.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Luo M, Liu Z, Hu Z, He Q. Quercetin improves contrast-induced acute kidney injury through the HIF-1alpha/lncRNA NEAT1/HMGB1 pathway. Pharm Biol. 2022;60(1):889–98.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Lei L, Xue Y, Guo Z, Liu B, He Y, Song F, et al. A comparison between different definitions of contrast-induced acute kidney injury for long-term mortality in patients with acute myocardial infarction. Int J Cardiol Heart Vasculature. 2020;28:100522.

    Article 

    Google Scholar
     

  • Wang H, Gao T, Zhang R, Hu J, Wang Y, Wei J, et al. The intellectual base and global trends in contrast-induced acute kidney injury: a bibliometric analysis. Ren Fail. 2023;45(1):2188967.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Lohani S, Rudnick MR. Contrast media-different types of contrast media, their history, Chemical Properties, and relative nephrotoxicity. Interventional Cardiol Clin. 2020;9(3):279–92.

    Article 

    Google Scholar
     

  • Kafkas N, Liakos C, Zoubouloglou F, Dagadaki O, Dragasis S, Makris K. Neutrophil Gelatinase-Associated Lipocalin as an early marker of contrast-Induced Nephropathy after Elective Invasive Cardiac procedures. Clin Cardiol. 2016;39(8):464–70.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Molitoris BA. Urinary biomarkers: alone are they enough? J Am Soc Nephrol. 2015;26(7):1485–8.

    Article 
    PubMed 

    Google Scholar
     

  • Singh K, Bhargava V, Brar JE, Bhargava M, Kaushal R, Khullar D. Contrast Induced Acute kidney Injury (CI- AKI) – myths and realities. J Assoc Phys India. 2021;69(11):11–2.


    Google Scholar
     

  • Griesmann H, Muhl S, Riedel J, Theuerkorn K, Sipos B, Esposito I et al. CUX1 enhances pancreatic Cancer formation by synergizing with KRAS and Inducing MEK/ERK-Dependent Proliferation. Cancers (Basel). 2021;13(10).

  • Sándor Z, Katics D, Varga Á, Kalmár Nagy K, Szakály P. Interpretation of LDH values after kidney transplantation. J Clin Med. 2024;13(2).

  • Fu Y, Cao J, Wei X, Ge Y, Su Z, Yu D. Klotho alleviates contrast-induced acute kidney injury by suppressing oxidative stress, inflammation, and NF-KappaB/NLRP3-mediated pyroptosis. Int Immunopharmacol. 2023;118:110105.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Aly M, Ramdzan ZM, Nagata Y, Balasubramanian SK, Hosono N, Makishima H, et al. Distinct clinical and biological implications of CUX1 in myeloid neoplasms. Blood Adv. 2019;3(14):2164–78.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Zhou H, Huang S, Lv X, Wang S, Cao X, Yuan Z et al. Effect of CUX1 on the proliferation of Hu Sheep dermal papilla cells and on the Wnt/β-Catenin signaling pathway. Genes. 2023;14(2).

  • Song L, Yao S, Zheng D, Xuan Y, Li W. Astaxanthin attenuates contrast-induced acute kidney injury in rats via ROS/NLRP3 inflammasome. Int Urol Nephrol. 2022;54(6):1355–64.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Yu R, Wu C, Xiao Y, Li Q, Chen J, Song J, et al. The clinical predictive value and regulation mechanism of microRNA-188-5p in contrast-induced acute kidney injury. Biochem Biophys Res Commun. 2023;679:215–23.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Ramdzan ZM, Ginjala V, Pinder JB, Chung D, Donovan CM, Kaur S, et al. The DNA repair function of CUX1 contributes to radioresistance. Oncotarget. 2017;8(12):19021–38.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Ramdzan ZM, Vadnais C, Pal R, Vandal G, Cadieux C, Leduy L, et al. RAS transformation requires CUX1-dependent repair of oxidative DNA damage. PLoS Biol. 2014;12(3):e1001807.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Guan XF, Chen QJ, Zuo XC, Guo R, Peng XD, Wang JL, et al. Contrast Media-Induced Renal inflammation is mediated through HMGB1 and its receptors in human tubular cells. DNA Cell Biol. 2017;36(1):67–76.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Wang X, Zhou J, Yang J, Wang S, Yang L. Role of TLR4/MyD88/NF-κB signaling in the contrast-induced injury of renal tubular epithelial cells. Experimental Therapeutic Med. 2020;20(5):115.

    Article 

    Google Scholar
     

  • Slowikowski K, Nguyen HN, Noss EH, Simmons DP, Mizoguchi F, Watts GFM, et al. CUX1 and IkappaBzeta (NFKBIZ) mediate the synergistic inflammatory response to TNF and IL-17A in stromal fibroblasts. Proc Natl Acad Sci U S A. 2020;117(10):5532–41.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Zhao Y, Feng X, Li B, Sha J, Wang C, Yang T, et al. Dexmedetomidine protects against Lipopolysaccharide-Induced Acute kidney Injury by enhancing Autophagy through inhibition of the PI3K/AKT/mTOR pathway. Front Pharmacol. 2020;11:128.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Zhang BH, Liu H, Yuan Y, Weng XD, Du Y, Chen H, et al. Knockdown of TRIM8 protects HK-2 cells against Hypoxia/Reoxygenation-Induced Injury by inhibiting oxidative stress-mediated apoptosis and pyroptosis via PI3K/Akt Signal Pathway. Drug Des Devel Ther. 2021;15:4973–83.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Li X, Shi J, Teng Y, Liu Z. The preventative effect of Baihe Gujin Pill on cisplatin-induced acute kidney injury by activating the PI3K/AKT and suppressing the NF-κB/MAPK pathways. J Ethnopharmacol. 2024;318(Pt B):117071.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Xie XC, Cao Y, Yang X, Xu QH, Wei W, Wang M. Relaxin attenuates contrast-Induced Human Proximal Tubular Epithelial Cell apoptosis by activation of the PI3K/Akt signaling pathway in Vitro. Biomed Res Int. 2017;2017:2869405.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Tongqiang L, Shaopeng L, Xiaofang Y, et al. Salvianolic acid B prevents Iodinated contrast Media-Induced Acute Renal Injury in rats via the PI3K/Akt/Nrf2 pathway. Oxid Med Cell Longev. 2016;2016:7079487.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Guo Y, Li W, Qian M, Jiang T, Guo P, Du Q, et al. D-4F ameliorates contrast Media-Induced oxidative injuries in endothelial cells via the AMPK/PKC pathway. Front Pharmacol. 2020;11:556074.

    Article 
    CAS 
    PubMed 

    Google Scholar