Li Q, Yang Y, Reis C, Tao T, Li W, Li X, Zhang JH. Cerebral small Vessel Disease. Cell Transpl. 2018;27(12):1711–22.
Cannistraro RJ, Badi M, Eidelman BH, Dickson DW, Middlebrooks EH, Meschia JF. CNS small vessel disease: a clinical review. Neurology. 2019;92(24):1146–56.
Romero JR. Simple interventions: A Clue to Tackle Cerebral Small Vessel Disease. Stroke. 2022;53(9):2868–9.
Mu R, Qin X, Guo Z, Meng Z, Liu F, Zhuang Z, Zheng W, Li X, Yang P, Feng Y, et al. Prevalence and consequences of Cerebral Small Vessel diseases: a cross-sectional study based on Community people Plotted against 5-Year age strata. Neuropsychiatr Dis Treat. 2022;18:499–512.
Poels MM, Vernooij MW, Ikram MA, Hofman A, Krestin GP, van der Lugt A, Breteler MM. Prevalence and risk factors of cerebral microbleeds: an update of the Rotterdam scan study. Stroke. 2010;41(10 Suppl):103–6.
Nylander R, Fahlstrom M, Rostrup E, Kullberg J, Damangir S, Ahlstrom H, Lind L, Larsson EM. Quantitative and qualitative MRI evaluation of cerebral small vessel disease in an elderly population: a longitudinal study. Acta Radiol. 2018;59(5):612–8.
Zhang QL, Rothenbacher D. Prevalence of chronic kidney disease in population-based studies: systematic review. BMC Public Health. 2008;8:117.
Berger I, Wu S, Masson P, Kelly PJ, Duthie FA, Whiteley W, Parker D, Gillespie D, Webster AC. Cognition in chronic kidney disease: a systematic review and meta-analysis. BMC Med. 2016;14(1):206.
Mansson T, Overton M, Pihlsgard M, Elmstahl S. Impaired kidney function is associated with lower cognitive function in the elder general population. Results from the good aging in Skane (GAS) cohort study. BMC Geriatr. 2019;19(1):360.
Mansson T, Elmstahl S. Processing speed is affected by early impairment in kidney function in the general elder population. BMC Nephrol. 2021;22(1):314.
Dey AK, Stamenova V, Turner G, Black SE, Levine B. Pathoconnectomics of cognitive impairment in small vessel disease: a systematic review. Alzheimers Dement. 2016;12(7):831–45.
Sachdev PS, Blacker D, Blazer DG, Ganguli M, Jeste DV, Paulsen JS, Petersen RC. Classifying neurocognitive disorders: the DSM-5 approach. Nat Rev Neurol. 2014;10(11):634–42.
Lau WL, Huisa BN, Fisher M. The cerebrovascular-chronic kidney disease connection: perspectives and mechanisms. Transl Stroke Res. 2017;8(1):67–76.
O’Rourke MF, Safar ME. Relationship between aortic stiffening and microvascular disease in brain and kidney: cause and logic of therapy. Hypertension. 2005;46(1):200–4.
Jankowski J, Floege J, Fliser D, Bohm M, Marx N. Cardiovascular Disease in chronic kidney disease: pathophysiological insights and therapeutic options. Circulation. 2021;143(11):1157–72.
Arinze NV, Gregory A, Francis JM, Farber A, Chitalia VC. Unique aspects of peripheral artery disease in patients with chronic kidney disease. Vasc Med. 2019;24(3):251–60.
Xiao C-Y, Ma Y-H, Ou Y-N, Zhao B, Hu H-Y, Wang Z-T, Tan L. Association between kidney function and the Burden of Cerebral Small Vessel Disease: an updated Meta-analysis and systematic review. Cerebrovasc Dis 2023:1–11.
Liu Y, Lv P, Jin H, Cui W, Niu C, Zhao M, Fan C, Teng Y, Pan B, Peng Q, et al. Association between low estimated glomerular filtration rate and risk of Cerebral Small-Vessel diseases: a Meta-analysis. J Stroke Cerebrovasc Dis. 2016;25(3):710–6.
Makin SD, Cook FA, Dennis MS, Wardlaw JM. Cerebral small vessel disease and renal function: systematic review and meta-analysis. Cerebrovasc Dis. 2015;39(1):39–52.
Vogels SC, Emmelot-Vonk MH, Verhaar HJ, Koek HL. The association of chronic kidney disease with brain lesions on MRI or CT: a systematic review. Maturitas. 2012;71(4):331–6.
Mozaffarian D, Benjamin EJ, Go AS, Arnett DK, Blaha MJ, Cushman M, de Ferranti S, Despres JP, Fullerton HJ, Howard VJ, et al. Heart disease and stroke statistics–2015 update: a report from the American Heart Association. Circulation. 2015;131(4):e29–322.
Ekström H, Elmståhl S. Pain and fractures are independently related to lower walking speed and grip strength: results from the population study Good Ageing in Skåne / Pain and fractures are independently related to lower walking speed and grip strength: results from the population study good ageing in Skåne. Acta Orthop 2006(6):902.
Lagergren M, Fratiglioni L, Hallberg IR, Berglund J, Elmstahl S, Hagberg B, Holst G, Rennemark M, Sjolund BM, Thorslund M, et al. A longitudinal study integrating population, care and social services data. The Swedish National study on aging and care (SNAC). Aging Clin Exp Res. 2004;16(2):158–68.
Legrand H, Werner K, Christensson A, Pihlsgård M, Elmståhl S. Prevalence and determinants of differences in cystatin C and creatinine-based estimated glomerular filtration rate in community-dwelling older adults: a cross-sectional study. BMC Nephrol. 2017;18(1):350.
Kidney Disease. Improving global outcomes (KDIGO) CKD Work Group. KDIGO 2012 Clinical Practice Guideline for the evaluation and management of chronic kidney disease. Kidney inter Suppl. 2013;3:1–150.
Levey AS, Stevens LA, Schmid CH, Zhang YL, Castro AF 3rd, Feldman HI, Kusek JW, Eggers P, Van Lente F, Greene T, et al. A new equation to estimate glomerular filtration rate. Ann Intern Med. 2009;150(9):604–12.
Inker LA, Schmid CH, Tighiouart H, Eckfeldt JH, Feldman HI, Greene T, Kusek JW, Manzi J, Van Lente F, Zhang YL, et al. Estimating glomerular filtration rate from serum creatinine and cystatin C. N Engl J Med. 2012;367(1):20–9.
Porter Starr KN, Bales CW. Excessive body weight in older adults. Clin Geriatr Med. 2015;31(3):311–26.
Nankivell BJ, Nankivell LFJ, Elder GJ, Gruenewald SM. How unmeasured muscle mass affects estimated GFR and diagnostic inaccuracy. EClinicalMedicine 2020, 29–30:100662.
Elmstahl S, Ellstrom K, Siennicki-Lantz A, Abul-Kasim K. Association between cerebral microbleeds and hypertension in the Swedish general population good aging in Skane study. J Clin Hypertens (Greenwich). 2019;21(8):1099–107.
Fazekas F, Chawluk JB, Alavi A, Hurtig HI, Zimmerman RA. MR signal abnormalities at 1.5 T in Alzheimer’s dementia and normal aging. AJR Am J Roentgenol. 1987;149(2):351–6.
Offenbacher H, Fazekas F, Schmidt R, Koch M, Fazekas G, Kapeller P. MR of cerebral abnormalities concomitant with primary intracerebral hematomas. AJNR Am J Neuroradiol. 1996;17(3):573–8.
Pasquier F, Leys D, Weerts JG, Mounier-Vehier F, Barkhof F, Scheltens P. Inter- and intraobserver reproducibility of cerebral atrophy assessment on MRI scans with hemispheric infarcts. Eur Neurol. 1996;36(5):268–72.
Koedam EL, Lehmann M, van der Flier WM, Scheltens P, Pijnenburg YA, Fox N, Barkhof F, Wattjes MP. Visual assessment of posterior atrophy development of a MRI rating scale. Eur Radiol. 2011;21(12):2618–25.
Staals J, Makin SD, Doubal FN, Dennis MS, Wardlaw JM. Stroke subtype, vascular risk factors, and total MRI brain small-vessel disease burden. Neurology. 2014;83(14):1228–34.
Wardlaw JM, Smith EE, Biessels GJ, Cordonnier C, Fazekas F, Frayne R, Lindley RI, O’Brien JT, Barkhof F, Benavente OR, et al. Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration. Lancet Neurol. 2013;12(8):822–38.
Kim SH, Shin DW, Yun JM, Lee JE, Lim JS, Cho BL, Kwon HM, Park JH. Kidney dysfunction and cerebral microbleeds in neurologically healthy adults. PLoS ONE. 2017;12(2):e0172210.
Shima H, Ishimura E, Naganuma T, Yamazaki T, Kobayashi I, Shidara K, Mori K, Takemoto Y, Shoji T, Inaba M, et al. Cerebral microbleeds in predialysis patients with chronic kidney disease. Nephrol Dial Transpl. 2010;25(5):1554–9.
van Overbeek EC, Staals J, van Oostenbrugge RJ. Decreased kidney function relates to progression of cerebral microbleeds in lacunar stroke patients. Int J Stroke. 2016;11(6):695–700.
McFadden EC, Hirst JA, Verbakel JY, McLellan JH, Hobbs FDR, Stevens RJ, O’Callaghan CA, Lasserson DS. Systematic review and metaanalysis comparing the Bias and Accuracy of the modification of Diet in Renal Disease and chronic kidney disease epidemiology collaboration equations in community-based populations. Clin Chem. 2018;64(3):475–85.
Akoudad S, Sedaghat S, Hofman A, Koudstaal PJ, van der Lugt A, Ikram MA, Vernooij MW. Kidney function and cerebral small vessel disease in the general population. Int J Stroke. 2015;10(4):603–8.
Sedaghat S, Ding J, Eiriksdottir G, van Buchem MA, Sigurdsson S, Ikram MA, Meirelles O, Gudnason V, Levey AS, Launer LJ. The AGES-Reykjavik Study suggests that change in kidney measures is associated with subclinical brain pathology in older community-dwelling persons. Kidney Int. 2018;94(3):608–15.
Jimenez-Balado J, Riba-Llena I, Pizarro J, Palasi A, Penalba A, Ramirez C, Maisterra O, Espinel E, Ramos N, Pujadas F, et al. Kidney function changes and their relation with the progression of cerebral small vessel disease and cognitive decline. J Neurol Sci. 2020;409:116635.
Yakushiji Y, Nanri Y, Hirotsu T, Nishihara M, Hara M, Nakajima J, Eriguchi M, Nishiyama M, Hara H, Node K. Marked cerebral atrophy is correlated with kidney dysfunction in nondisabled adults. Hypertens Res. 2010;33(12):1232–7.
Chang CY, Lin CC, Tsai CF, Yang WC, Wang SJ, Lin FH, Fuh JL. Cognitive impairment and hippocampal atrophy in chronic kidney disease. Acta Neurol Scand. 2017;136(5):477–85.
Ikram MA, Vernooij MW, Hofman A, Niessen WJ, van der Lugt A, Breteler MM. Kidney function is related to cerebral small vessel disease. Stroke. 2008;39(1):55–61.
Staplin N, Herrington WG, Murgia F, Ibrahim M, Bull KR, Judge PK, Ng SYA, Turner M, Zhu D, Emberson J, et al. Determining the relationship between blood pressure, kidney function, and chronic kidney disease: insights from genetic epidemiology. Hypertension. 2022;79(12):2671–81.
Newby D, Winchester L, Sproviero W, Fernandes M, Wang D, Kormilitzin A, Launer LJ, Nevado-Holgado AJ. Associations between Brain volumes and cognitive tests with hypertensive Burden in UK Biobank. J Alzheimers Dis. 2021;84(3):1373–89.
Petrea RE, O’Donnell A, Beiser AS, Habes M, Aparicio H, DeCarli C, Seshadri S, Romero JR. Mid to Late Life Hypertension trends and Cerebral Small Vessel Disease in the Framingham Heart Study. Hypertension. 2020;76(3):707–14.
Jimenez-Balado J, Riba-Llena I, Maisterra O, Pizarro J, Palasi A, Pujadas F, Mundet X, Vinyoles E, Delgado P. Ambulatory blood pressure levels in the prediction of progression of Cerebral Small Vessel Disease. J Am Geriatr Soc. 2020;68(10):2232–9.
Zhang D, Zhang J, Zhang B, Zhang J, He M. Association of blood pressure, White Matter lesions, and Regional Cerebral Blood Flow. Med Sci Monit. 2021;27:e929958.
Nobili F, Rodriguez G, Marenco S, De Carli F, Gambaro M, Castello C, Pontremoli R, Rosadini G. Regional cerebral blood flow in chronic hypertension. A correlative study. Stroke. 1993;24(8):1148–53.
Safar ME, Asmar R, Benetos A, Blacher J, Boutouyrie P, Lacolley P, Laurent S, London G, Pannier B, Protogerou A, et al. Interaction between Hypertension and arterial stiffness. Hypertension. 2018;72(4):796–805.
Zhai FF, Ye YC, Chen SY, Ding FM, Han F, Yang XL, Wang Q, Zhou LX, Ni J, Yao M, et al. Arterial stiffness and cerebral small Vessel Disease. Front Neurol. 2018;9:723.
Ellstrom K, Abul-Kasim K, Siennicki-Lantz A, Elmstahl S. Associations of carotid artery flow parameters with MRI markers of cerebral small vessel disease and patterns of brain atrophy. J Stroke Cerebrovasc Dis. 2023;32(3):106981.
Safar ME, London GM, Plante GE. Arterial stiffness and kidney function. Hypertension. 2004;43(2):163–8.
Vanhoutte PM, Shimokawa H, Tang EH, Feletou M. Endothelial dysfunction and vascular disease. Acta Physiol (Oxf). 2009;196(2):193–222.
Roumeliotis S, Mallamaci F, Zoccali C. Endothelial dysfunction in chronic kidney Disease, from Biology to Clinical outcomes: a 2020 Update. J Clin Med 2020, 9(8).
Bai T, Yu S, Feng J. Advances in the role of endothelial cells in Cerebral Small Vessel Disease. Front Neurol. 2022;13:861714.
Setiadi A, Korim WS, Elsaafien K, Yao ST. The role of the blood-brain barrier in hypertension. Exp Physiol. 2018;103(3):337–42.
Arnold R, Issar T, Krishnan AV, Pussell BA. Neurological complications in chronic kidney disease. JRSM Cardiovasc Dis. 2016;5:2048004016677687.
Lau WL, Nunes ACF, Vasilevko V, Floriolli D, Lertpanit L, Savoj J, Bangash M, Yao Z, Shah K, Naqvi S, et al. Chronic kidney Disease increases cerebral microbleeds in Mouse and Man. Transl Stroke Res. 2020;11(1):122–34.
Seliger SL, Salimi S, Pierre V, Giffuni J, Katzel L, Parsa A. Microvascular endothelial dysfunction is associated with albuminuria and CKD in older adults. BMC Nephrol. 2016;17(1):82.
Zou LX, Sun L, Nicholas SB, Lu Y, K SS, Hua R. Comparison of bias and accuracy using cystatin C and creatinine in CKD-EPI equations for GFR estimation. Eur J Intern Med. 2020;80:29–34.
Legrand H, Werner K, Christensson A, Pihlsgard M, Elmstahl S. Prevalence and determinants of differences in cystatin C and creatinine-based estimated glomerular filtration rate in community-dwelling older adults: a cross-sectional study. BMC Nephrol. 2017;18(1):350.
Hao R, Guo H. Anorexia, undernutrition, weight loss, Sarcopenia, and cachexia of aging. Eur Rev Aging Phys Activity. 2012;9(2):119–27.
Kanhai DA, de Kappelle KDF. LJ, Kappelle Lj Fau – Uiterwaal CSPM, Uiterwaal Cs Fau – van der Graaf Y, van der Graaf Y Fau – Pasterkamp G, Pasterkamp G Fau – Geerlings MI, Geerlings Mi Fau – Visseren FLJ, Visseren FL: Extracellular vesicle protein levels are related to brain atrophy and cerebral white matter lesions in patients with manifest vascular disease: the SMART-MR study. (2044–6055 (Print)).
Grubb A, Lindstrom V, Jonsson M, Back SE, Ahlund T, Rippe B, Christensson A. Reduction in glomerular pore size is not restricted to pregnant women. Evidence for a new syndrome: ‘Shrunken pore syndrome’. Scand J Clin Lab Invest. 2015;75(4):333–40.
Almen MS, Bjork J, Nyman U, Lindstrom V, Jonsson M, Abrahamson M, Vestergren AS, Lindhe O, Franklin G, Christensson A, et al. Shrunken pore syndrome is Associated with increased levels of atherosclerosis-promoting proteins. Kidney Int Rep. 2019;4(1):67–79.
Zhao L, Lee A, Fan YH, Mok VCT, Shi L. Magnetic resonance imaging manifestations of cerebral small vessel disease: automated quantification and clinical application. Chin Med J (Engl). 2020;134(2):151–60.
Nitkunan A, Lanfranconi S, Charlton RA, Barrick TR, Markus HS. Brain atrophy and cerebral small vessel disease: a prospective follow-up study. Stroke. 2011;42(1):133–8.
Litak J, Mazurek M, Kulesza B, Szmygin P, Litak J, Kamieniak P, Grochowski C. Cerebral Small Vessel Disease. Int J Mol Sci 2020, 21(24).
Li X, Yuan J, Qin W, Yang L, Yang S, Li Y, Hu W. Higher total cerebral small Vessel Disease Burden was Associated with mild cognitive impairment and overall cognitive dysfunction: a propensity score-matched case-control study. Front Aging Neurosci. 2021;13:695732.
Fan Y, Xu Y, Shen M, Guo H, Zhang Z. Total cerebral small Vessel Disease Burden on MRI correlates with cognitive impairment in outpatients with Amnestic disorders. Front Neurol. 2021;12:747115.
Goldstein ED, Badi MK, Hasan TF, Lesser ER, Hodge DO, Lin MP, Meschia JF. Cerebral small Vessel Disease Burden and all-cause mortality: Mayo Clinic Florida familial cerebrovascular diseases Registry. J Stroke Cerebrovasc Dis. 2019;28(12):104285.
Rhodius-Meester HFM, Benedictus MR, Wattjes MP, Barkhof F, Scheltens P, Muller M, van der Flier WM. MRI visual ratings of Brain Atrophy and White Matter hyperintensities across the Spectrum of Cognitive decline are differently affected by age and diagnosis. Front Aging Neurosci. 2017;9:117.
Roob G, Schmidt R, Kapeller P, Lechner A, Hartung HP, Fazekas F. MRI evidence of past cerebral microbleeds in a healthy elderly population. Neurology. 1999;52(5):991–4.
- The Renal Warrior Project. Join Now
- Source: https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882-024-03528-8