The solution
Donated kidneys are usually put in cold storage to keep them as healthy as possible throughout the time between donation and transplantation. With support from Kidney Research UK, John and his colleagues will investigate whether NMP (during which warm, oxygen-rich blood is pumped round a donated kidney prior to transplantation) can be used to deliver medications to donated kidneys to improve their condition and maximise the chance of them working well after transplantation.
John will look at whether treatments delivered to donated kidneys that would usually have been considered unsuitable for transplant can improve their condition so that they would meet the standard needed to be used in a patient awaiting a new kidney. In particular, he will assess the impact of using medicines which can reduce formation of blood clots and protect the vulnerable cells that line kidney blood vessels.