Search
Search
Close this search box.

Associations of systemic inflammatory regulators with CKD and kidney function: evidence from the bidirectional mendelian randomization study – BMC Nephrology

  • Kalantar-Zadeh K, Jafar TH, Nitsch D, Neuen BL, Perkovic V. Chronic kidney disease. Lancet. 2021;398:786–802.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Xie Y, Bowe B, Mokdad AH, Xian H, Yan Y, Li T, et al. Analysis of the Global Burden of Disease study highlights the global, regional, and national trends of chronic kidney disease epidemiology from 1990 to 2016. Kidney Int. 2018;94:567–81.

    Article 
    PubMed 

    Google Scholar
     

  • Webster AC, Nagler EV, Morton RL, Masson P. Chronic kidney disease. Lancet. 2017;389:1238–52.

    Article 
    PubMed 

    Google Scholar
     

  • Tamura MK, Desai M, Kapphahn KI, Thomas I-C, Asch SM, Chertow GM. Dialysis versus medical management at different ages and levels of kidney function in veterans with advanced CKD. J Am Soc Nephrol. 2018;29:2169–77.

    Article 

    Google Scholar
     

  • Cobo G, Lindholm B, Stenvinkel P. Chronic inflammation in end-stage renal disease and dialysis. Nephrol Dial Transpl. 2018;33:iii35–40.

    Article 
    CAS 

    Google Scholar
     

  • Mihai S, Codrici E, Popescu ID, Enciu A-M, Albulescu L, Necula LG et al. Inflammation-related mechanisms in chronic kidney disease prediction, progression, and outcome. J Immunol Res. 2018;2018:2180373.

  • Rapa SF, Di Iorio BR, Campiglia P, Heidland A, Marzocco S. Inflammation and oxidative stress in chronic kidney disease—potential therapeutic role of minerals, vitamins and plant-derived metabolites. Int J Mol Sci. 2019;21:263.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Petreski T, Piko N, Ekart R, Hojs R, Bevc S. Review on inflammation markers in chronic kidney disease. Biomedicines. 2021;9:182.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Bazeley J, Bieber B, Li Y, Morgenstern H, de Sequera P, Combe C, et al. C-reactive protein and prediction of 1-year mortality in prevalent hemodialysis patients. Clin J Am Soc Nephrol. 2011;6:2452–61.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Burgess S, Butterworth A, Thompson SG. Mendelian randomization analysis with multiple genetic variants using summarized data. Genet Epidemiol. 2013;37:658–65.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Emdin CA, Khera AV, Kathiresan S. Mendelian randomization. JAMA. 2017;318:1925–6.

    Article 
    PubMed 

    Google Scholar
     

  • Sanderson E, Glymour MM, Holmes MV, Kang H, Morrison J, Munafò MR, et al. Mendelian randomization. Nat Rev Methods Primers. 2022;2:1–21.

    Article 

    Google Scholar
     

  • Ahola-Olli AV, Würtz P, Havulinna AS, Aalto K, Pitkänen N, Lehtimäki T, et al. Genome-wide association study identifies 27 loci influencing concentrations of circulating cytokines and growth factors. Am J Hum Genet. 2017;100:40–50.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Wuttke M, Li Y, Li M, Sieber KB, Feitosa MF, Gorski M, et al. A catalog of genetic loci associated with kidney function from analyses of a million individuals. Nat Genet. 2019;51:957–72.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Stanzick KJ, Li Y, Schlosser P, Gorski M, Wuttke M, Thomas LF, et al. Discovery and prioritization of variants and genes for kidney function in > 1.2 million individuals. Nat Commun. 2021;12:1–17.

    Article 

    Google Scholar
     

  • Clarke L, Zheng-Bradley X, Smith R, Kulesha E, Xiao C, Toneva I, et al. The 1000 Genomes Project: data management and community access. Nat Methods. 2012;9:459–62.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Burgess S, Thompson SG, Collaboration CCG. Avoiding bias from weak instruments in mendelian randomization studies. Int J Epidemiol. 2011;40:755–64.

    Article 
    PubMed 

    Google Scholar
     

  • Guo J, Yu K, Dong S-S, Yao S, Rong Y, Wu H, et al. Mendelian randomization analyses support causal relationships between brain imaging-derived phenotypes and risk of psychiatric disorders. Nat Neurosci. 2022;25:1519–27.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Palmer TM, Lawlor DA, Harbord RM, Sheehan NA, Tobias JH, Timpson NJ, et al. Using multiple genetic variants as instrumental variables for modifiable risk factors. Stat Methods Med Res. 2012;21:223–42.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Hartwig FP, Davies NM, Hemani G, Davey Smith G. Two-sample mendelian randomization: avoiding the downsides of a powerful, widely applicable but potentially fallible technique. Int J Epidemiol. 2016;45:1717–26.

    Article 
    PubMed 

    Google Scholar
     

  • Verbanck M, Chen CY, Neale B, Do R. Detection of widespread horizontal pleiotropy in causal relationships inferred from mendelian randomization between complex traits and diseases. Nat Genet. 2018;50:693–8.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Burgess S, Foley CN, Allara E, Staley JR, Howson JMM. A robust and efficient method for mendelian randomization with hundreds of genetic variants. Nat Commun. 2020;11:376.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Bowden J, Davey Smith G, Burgess S. Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression. Int J Epidemiol. 2015;44:512–25.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Bowden J, Davey Smith G, Haycock PC, Burgess S. Consistent estimation in mendelian randomization with some Invalid instruments using a weighted median estimator. Genet Epidemiol. 2016;40:304–14.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Yazdi AS, Ghoreschi K. The Interleukin-1 family. Adv Exp Med Biol. 2016;941:21–9.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Palomo J, Dietrich D, Martin P, Palmer G, Gabay C. The interleukin (IL)-1 cytokine family–balance between agonists and antagonists in inflammatory diseases. Cytokine. 2015;76:25–37.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Gupta J, Mitra N, Kanetsky PA, Devaney J, Wing MR, Reilly M, et al. Association between albuminuria, kidney function, and inflammatory biomarker profile in CKD in CRIC. Clin J Am Soc Nephrol. 2012;7:1938–46.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Pruijm M, Ponte B, Vollenweider P, Mooser V, Paccaud F, Waeber G, et al. Not all inflammatory markers are linked to kidney function: results from a population-based study. Am J Nephrol. 2012;35:288–94.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Amdur RL, Feldman HI, Gupta J, Yang W, Kanetsky P, Shlipak M, et al. Inflammation and progression of CKD: the CRIC Study. Clin J Am Soc Nephrol. 2016;11:1546–56.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Dinarello CA, Novick D, Kim S, Kaplanski G. Interleukin-18 and IL-18 binding protein. Front Immunol. 2013;4:289.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Bani-Hani AH, Leslie JA, Asanuma H, Dinarello CA, Campbell MT, Meldrum DR, et al. IL-18 neutralization ameliorates obstruction-induced epithelial-mesenchymal transition and renal fibrosis. Kidney Int. 2009;76:500–11.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Luan J, Fu J, Jiao C, Hao X, Feng Z, Zhu L, et al. IL-18 deficiency ameliorates the progression from AKI to CKD. Cell Death Dis. 2022;13:957.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Ralston JC, Lyons CL, Kennedy EB, Kirwan AM, Roche HM. Fatty acids and NLRP3 inflammasome-mediated inflammation in metabolic tissues. Annu Rev Nutr. 2017;37:77–102.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • He Y, Hara H, Núñez G. Mechanism and regulation of NLRP3 inflammasome activation. Trends Biochem Sci. 2016;41:1012–21.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Ferrucci L, Fabbri E. Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty. Nat Rev Cardiol. 2018;15:505–22.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Mertowska P, Mertowski S, Smarz-Widelska I, Grywalska E. Biological role, mechanism of action and the importance of interleukins in kidney diseases. Int J Mol Sci. 2022;23:647.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Williams JW, Huang LH, Randolph GJ. Cytokine circuits in Cardiovascular Disease. Immunity. 2019;50:941–54.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Coller BS. Leukocytosis and ischemic vascular disease morbidity and mortality: is it time to intervene? Arterioscler Thromb Vasc Biol. 2005;25:658–70.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Rossignol P, Duarte K, Bresso E, Åsberg A, Devignes M, Eriksson N, et al. NT-proBNP and stem cell factor plasma concentrations are independently associated with cardiovascular outcomes in end-stage renal disease hemodialysis patients. Eur Heart J Open. 2022;2(6):oeac069.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Cortvrindt C, Speeckaert R, Moerman A, Delanghe JR, Speeckaert MM. The role of interleukin-17A in the pathogenesis of kidney diseases. Pathology. 2017;49:247–58.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Mehrotra P, Collett JA, McKinney SD, Stevens J, Ivancic CM, Basile DP. IL-17 mediates neutrophil infiltration and renal fibrosis following recovery from ischemia reperfusion: compensatory role of natural killer cells in athymic rats. Am J Physiol Ren Physiol. 2017;312:F385–97.

    Article 
    CAS 

    Google Scholar
     

  • Biswas PS. IL-17 in renal immunity and autoimmunity. J Immunol. 2018;201:3153–9.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Schmidt T, Luebbe J, Paust HJ, Panzer U. Mechanisms and functions of IL-17 signaling in renal autoimmune diseases. Mol Immunol. 2018;104:90–9.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Koga T, Ichinose K, Tsokos GC. T cells and IL-17 in lupus nephritis. Clin Immunol. 2017;185:95–9.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Krebs CF, Schmidt T, Riedel JH, Panzer U. T helper type 17 cells in immune-mediated glomerular disease. Nat Rev Nephrol. 2017;13:647–59.

    Article 
    CAS 
    PubMed 

    Google Scholar